Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays

نویسندگان

  • Eric de Souza Gil
  • Maria Inês de Almeida Gonçalves
  • Elizabeth Igne Ferreira
  • Szulin Ber Zyngier
  • Renato Najjar
چکیده

The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by (13)C and (1)H NMR, infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells.

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عنوان ژورنال:
  • Metal-Based Drugs

دوره 6  شماره 

صفحات  -

تاریخ انتشار 1999